Put simply, dependent origination means that all phenomena arise as the result of conditions and cease when those conditions change. The Buddha taught the general theory of dependent origination as follows: “When this exists, that comes to be; with the arising of this, that arises. When this does not exist, that does not come to be; with the cessation of this, that ceases.” (Bodhi 2000, p. 575) So there-are-no static isolated entities in existence. Everything arises and ceases depending on causes and conditions that arise due to yet other causes and conditions. There is no ultimate ground or primordial cause, but a network of causes and conditions. This undercuts the view of a metaphysical selfhood, fixed entity, or substance underlying the constant change that is life.
Open Your Eyes, p176