It is stated in the Expenses and Food for Bodhisattva Way by Bodhisattva Nāgārjuna: “The World Honored One expounds the five rebellious sins, sinners of which are destined to fall into the Hell of Incessant Suffering. … If someone does not understand with faith the profound dharma and harbors an evil opinion regarding it, the sin of this person, compared to the one who commits the five rebellious sins, is many times, even hundreds of times heavier.”
Toki-dono Gosho, A Letter to Lord Toki, Writings of Nichiren Shōnin, Faith and Practice, Volume 4, Page 116-117