Then for Pukkusati’s sake Shakyamuni preached a sophisticated sermon, probably because he perceived that this man was of intellectual capacity sufficient for him to understand difficult Buddhist theories. The sermon was a detailed, logical presentation showing that human beings have six senses–sight, hearing, smell, taste, touch, and thought–for perceiving six objects: earth, water, fire, wind, air, and knowledge. From this operation of perception are born the sixteen kinds of emotions and sensations, including pain and pleasure and joy and sorrow. Knowledge of the nature and sources of these emotions lead to understanding of the truth that there is no permanent self and that there should be no attachments to conditioned phenomena. This in turn leads to paramount wisdom and the realization that nirvana is the ultimate Noble Truth. The person realizing this can attain the highest realm of tranquility by abandoning all things that cause delusions and by breaking with the three poisons of covetousness, anger, and delusion.
The Beginnings of Buddhism